Quantum analysis/improvement of antipsychotic's docking results
نویسندگان
چکیده
منابع مشابه
Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.
The complex etiology of schizophrenia has prompted researchers to develop clozapine-related multitarget strategies to combat its symptoms. Here we describe a series of new 6-aminomethylbenzofuranones in an effort to find new chemical structures with balanced affinities for 5-HT2 and dopamine receptors. Through biological and computational studies of 5-HT2A and D2 receptors, we identified the re...
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161 Antipsychotics
The first antipsychotic, chlorpromazine, was used for the treatment of psychosis in France in 1951 and in the United States in 1954. Antipsychotic use has expanded significantly since then. The historic term neuroleptic, used with antipsychotic medication, is no longer appropriate because newer agents cause less sedation. The term antipsychotic is now preferred. In 2009, U.S. poison control cen...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.810.9